王丽君，研究员、博士生导师。聚焦骨骼系统感知力学刺激的分子机制和失重性骨质疏松症的病理机制，并研究骨骼发育与退变的表观遗传调节机制。围绕上述研究方向，共发表SCI论文11篇，其中第一（含共同）作者6篇，包括Nature Communications（2022，共一第一）、Nature Communications（2020，唯一第一）、PLoS Biology（2018，共一第一）等。论文引用近500次，单篇最高引用200多次。获上海市扬帆计划人才项目支持，主持国家自然科学基金一项。
v 个人经历
2024.04-至今 海南医科大学（海南省医学科学院）PI、研究员、博士生导师
2024.01-2024.03 上海交通大学附属第六人民医院 副研究员、硕士生导师
2023.01-2023.12 上海交通大学附属第六人民医院 副研究员
2020.08-2022.12 上海交通大学附属第六人民医院 助理研究员
王丽君团队聚焦骨骼系统感知力学刺激的分子机制和失重性骨质疏松症的病理机制，并研究骨骼发育与退变的表观遗传调节机制。
v 代表性论著
1. Lijun Wang#, Xiuling You#, Dengfeng Ruan#, Rui Shao, Hai-Qiang Dai, Weiliang Shen, Guo-Liang Xu, Wanlu Liu*, Weiguo Zou*, TET proteins redundantly regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes. Nature communications 13, 4709 (2022) (IF: 17.694)
2. Lijun Wang, Xiuling You, Sutada Lotinun, Lingli Zhang, Nan Wu, Weiguo Zou*, Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk. Nature communications 11, 282 (2020) (IF: 17.694)
3. Lijun Wang, Xiuling You, Lingli Zhang, Changqing Zhang, Weiguo Zou, Mechanical regulation of bone remodeling. Bone Res 10, 16 (2022). (IF: 13.362)
4. Lijun Wang#, Ningning Niu#, Li Li#, Rui Shao, Huiling Ouyang, Weiguo Zou*, H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS biology 16, e2006522 (2018) (IF: 8.386)
5. Wei-Yang Bai#, Lijun Wang#, Zhi-Min Ying, Bin Hu, Lin Xu, Guo-Qing Zhang, Pei-Kuan Cong, Xiaofeng Zhu, Weiguo Zou*, Hou-Feng Zheng*, Identification of PIEZO1 polymorphisms for human bone mineral density. Bone 133, 115247 (2020) (IF:4.626)
6. Yilai Shu#, Lijun Wang#, Xiaoting Cheng, Chayada Tangshewinsirikul, Weili Shi, Yasheng Yuan, Zhiqiang Yan, Huawei Li, Jun Shen*, Bing Chen*, Weiguo Zou*, The p.(Pro170Leu) variant in NOG impairs noggin secretion and causes autosomal dominant congenital conductive hearing loss due to stapes ankylosis. Journal of genetics and genomics = Yi chuan xue bao 46, 445-449 (2019) (IF:5.732)
7. Jun Sun, Lingling Hu, Seoyeon Bok, Alisha R Yallowitz, Michelle Cung, Jason McCormick, Ling J Zheng, Shawon Debnath, Yuzhe Niu, Adrian Y Tan, Sarfaraz Lalani, Kyle W Morse, Daniel Shinn, Anthony Pajak, Mohammed Hammad, Vincentius Jeremy Suhardi, Zan Li, Na Li, Lijun Wang, Weiguo Zou, Vivek Mittal, Mathias P G Bostrom, Ren Xu, Sravisht Iyer, Matthew B Greenblatt, A vertebral skeletal stem cell lineage driving metastasis. Nature. 621(7979):602-609. (2023)
8. Danting Zhang, Weimin Lin, Shuang Jiang, Peng Deng, Linfeng Liu, Qian Wang, Rui Sheng, Hui Sophie Shu, Lijun Wang, Weiguo Zou, Bo O Zhou, Junjun Jing, Ling Ye, Bo Yu, Shiwen Zhang, Quan Yuan, Lepr-Expressing PDLSCs Contribute to Periodontal Homeostasis and Respond to Mechanical Force by Piezo1. Adv Sci (Weinh), 10(29): e2303291 (2023)
9. Shao Rui, Zhang Zhong, Xu Zhan, Ouyang Huiling, Wang Lijun, Ouyang Hongwei, Greenblatt Matthew, Chen Xi, Zou Weiguo, H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair. Bone Research, 2021, 9(1): 0-30 (IF: 13.362)
10. Meizhu Bai#, Yujiao Han#, Yuxuan Wu, Jiaoyang Liao, Lin Li, Lijun Wang, Qing Li, Wenhui Xing, Luonan Chen, Weiguo Zou*, Jinsong Li*, Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development. PLoS biology 17, e3000350 (2019) (IF: 8.386)
11. Ningning Niu#, Jian-Feng Xiang, Qin Yang, Lijun Wang, Zhanying Wei, Ling-Ling Chen, Li Yang, Weiguo Zou*, RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression. Cell discovery 3, 16050 (2017)
v 项目清单
1. 国家自然科学基金委员会/青年科学基金项目：机械敏感蛋白PIEZO1调节骨膜细胞促进骨骼修复的分子机制研究(82102554, 2022/1/1-202412/31)
2. 上海市科委/扬帆计划: DNA去甲基转移酶TET家族在骨发育中的分子机制研究(21YF1434500, 2021/5/1-2024/4/31)
3. 上海市第六人民医院/院级科学研究基金(2020/8/1-2023/7/31)
